Warframe's Nidus Prime Returns in 2026: Relic Farming and Plague Star Guide

As the Origin System continues to evolve into 2026, Warframe has once again brought back the highly sought-after Nidus Prime, delighting both veteran Tenno and newcomers alike. This infested juggernaut returns with refined aesthetics and the same devastating abilities, making it a must-have for collectors and combat enthusiasts. For those wondering how to secure this Prime variant, the path remains rooted in both direct purchase and dedicated free-range farming, with special events like Plague Star playing a pivotal role.

💎 Instant Acquisition: Nidus Prime Access Pack

The most straightforward method to add Nidus Prime to your arsenal is through the Nidus Prime Access Pack, which is available during this re-release window. Two bundles are on offer, each packed with exclusive content:

🔹 Nidus Prime Access Pack

• 2625 Platinum – a hefty amount of premium currency to bolster your inventory

• Nidus Prime – the Warframe itself, ready to use immediately

• Nidus Prime Glyphs – profile icons showcasing the infested artistry

• Strun Prime – a devastating prime shotgun

• Magnus Prime – a sleek prime sidearm

🔹 Nidus Prime Access Accessories Pack

• 1365 Platinum

• Crinoid Prime Syandana – a stylish back attachment

• Karnolyth Necramech Skin – customize your Necramech with an infested theme

• Infested Landing Craft Decorations – transform your Orbiter

• 90-Day Resource and Affinity Boosters – accelerate your progression

Purchasing these packs not only grants instant access but also supports the continued development of Warframe. However, many players prefer the thrill of the grind, and for them, the free-to-farm route is just as rewarding.

🧬 How to Farm Nidus Prime Relics for Free

Nidus Prime’s components are spread across different Void Relic types. You’ll need to collect the specific relics listed below and then crack them open by completing Void Fissure missions.

Component	Relic & Rarity
Chassis Blueprint	Lith N7 (Rare)
Systems Blueprint	Meso B5 (Common)
Blueprint	Axi A14 (Uncommon)
Neuroptics Blueprint	Neo N16 (Rare)

Acquiring these relics efficiently is key. While they drop from many standard missions, certain nodes are famous for their speed and reliability. Here’s a veteran-approved farming guide:

🟩 Lith Relics

• Best squad spot: Hepit, Void (Capture) – completes in under two minutes with a guaranteed Lith relic per run.

• Solo alternative: Same node works perfectly for solo players due to its simplicity.

🟨 Meso Relics

• Best squad spot: IO, Jupiter (Defense) – high density of enemies ensures rapid waves and frequent Meso drops.

• Solo alternative: Ukko, Void (Capture) – has an equal chance to drop Meso or Neo relics, making it a versatile choice.

🟦 Neo Relics

• Best squad spot: Oestrus, Eris (Infested Salvage) or dedicated Interception missions like Xini, Eris.

• Solo alternative: Again, Ukko in the Void is excellent, or you can run Lua Disruption for a change of pace.

🟥 Axi Relics

• Top options: Xini, Eris (Infested Interception) and Lua Disruption Node – both offer high rates.

• Solo alternative: Marduk, Void (Sabotage) – requires stealthy cache hunting but rewards patient Tenno.

As an additional bonus during special events, Plague Star provides a limited-time way to earn these relics directly from Konzu’s Bounty on the Plains of Eidolon. Completing the event missions awards Operational Supply Standing, which can then be spent on relic packs or exclusive event rewards.

☣️ How to Start Plague Star in 2026

Though Plague Star originated years ago, it has become a recurring event that reappears alongside major Prime Access rotations. To participate:

1. Travel to Cetus on Earth and speak with Konzu.

2. Select the Plague Star Bounty from his list of assignments.

3. Complete the multi-stage mission on the Plains, which involves mixing toxins, defending a mixer, and escorting a drone.

4. Earn Operational Supply Standing upon successful completion.

5. Visit Nakak in Cetus to spend your standing on event-specific items, including Forma, rare mods, and relic packs.

This event is not only a nostalgic throwback but also a prime opportunity to stockpile relics for Nidus Prime and other vaulted gear. Coordinating with a squad can drastically improve your efficiency, as each stage scales with team coordination.

🕹️ Final Tips for Aspiring Nidus Prime Owners

• Always run relic missions in a full squad when possible; it increases the variety of reward choices at the end.

• Upgrade relics with Void Traces to boost rare drop chances, especially for the Neuroptics and Chassis.

• Keep an eye on limited-time alerts and community streams for bonus relic drop weekends.

Nidus Prime’s unique playstyle, focusing on mutation stacks and crowd control, remains as thrilling as ever in 2026’s high-level content. Whether you choose the instant purchase or the free grind, this Prime Warframe is a formidable addition to your collection. The Plague Star event makes the journey even more festive, blending lore, challenge, and valuable loot into one chaotic package. Suit up, Tenno, and let the infestation spread!